Monday, 1 November 2010

A paper I wish I could understand

Sometimes papers in English might as well be in French. I found this to
see if there's any research on lithium causing demylination of the
corpus callosum. This was the first link.

http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1987.tb05657.x/abstract
Effect of Lithium on Schwann Cell Proliferation Stimulated by Axolemma-
and Myelin-Enriched Fractions

"
Cultured Schwann cells stimulated with an axolemma- or myelin-enriched
fraction incorporated 2.5 to three times as much [3H]thymidine when 10
mM lithium was added to the extracellular medium. The ability of lithium
to enhance the mitogenic activity of either fraction was dose dependent.
This result was not due to an increase in osmolarity, because addition
of 10 mM NaCl had no effect on the amount of labeled thymidine
accumulated by Schwann cells treated with either membrane fraction. In
an earlier study, the effect of either membrane fraction could be
potentiated with active phorbol esters. Lithium significantly enhanced
the incorporation of [3H]thymidine into Schwann cells treated with a
myelin-enriched fraction and phorbol esters. In contrast, lithium
slightly increased the amount of labeled thymidine incorporated into
Schwann cells stimulated with an axolemma-enriched fraction and phorbol
esters. The mitogenic activity of either membrane fraction was impaired
when the calcium channel blockers Mn2+ and nifedipine were added.
Addition of lithium stimulated an increase in the amount of
[3H]thymidine accumulated by Schwann cells treated with either the
axolemma- or myelin-enriched fraction in the presence of either Mn2+ or
nifedipine.
"

If I understand it right it might be relevant for either MS or other
brain conditions but wasn't what I was looking for.

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We It comes in part from an appreciation that no one can truly sign their own work. Everything is many influences coming together to the one moment where a work exists. The other is a begrudging acceptance that my work was never my own. There is another consciousness or non-corporeal entity that helps and harms me in everything I do. I am not I because of this force or entity. I am "we"