Wednesday 9 June 2010

Just how good is clozapine at treating schizophrenia?

From
http://priory.com/focus14.htm
"
Kane et al 1988 in their famous multicentre double-blind trial compared chlorpromazine with clozapine in equivalent doses and found that 4% chlorpromazine vs. 30% clozapine group responded by marked reduction in BPRS score (both positive and negative symptoms) in 6 weeks. 
Lieberman et al reported that the response rate of clozapine was 50% among previously treatment-refractory patients and 76% among treatment-intolerant patients.
Objective measures have indicated a marked improvement in psychopathology, including negative symptoms such as blunted affect, emotional withdrawal and apathy. (UK clozapine study group-1993,
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We It comes in part from an appreciation that no one can truly sign their own work. Everything is many influences coming together to the one moment where a work exists. The other is a begrudging acceptance that my work was never my own. There is another consciousness or non-corporeal entity that helps and harms me in everything I do. I am not I because of this force or entity. I am "we"