Will clozapine use increase

Doctors love to try effective treatments on other things.

The use of clozapine is already starting to be seen in other areas of medicine.

From
http://priory.com/focus14.htm

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Clozapine's beneficial use in several unlicensed disorders is being investigated, including psychosis secondary to dopaminergic therapy or coexisting psychiatric disorders in Parkinson's disease, other psychotic disorders, affective disorders, dyskinesias and related disorders, dementia, mental retardation, and polydipsia / hyponatraemia.
There are a number of reports, showing its dramatically beneficial effect in the patients with severe personality disorder where all other treatment options failed. These case reports and small studies show marked reduction in self harming behaviour, aggression and intensive affective response in this patient group (Frankenburge et al, 1993;Steinert et al, 1995;Chengappa et al , 1995; Benedetti et al, 1998).
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And
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Clozapine significantly decreases co-morbid use of alcohol and drugs in people with schizophrenia, possibly by reduction in craving (Harvard review of Psychiatry,1999)(Albanese et al-1994)(Frankenburg FR-1994). In one case study, a decrease in cocaine use after clozapine therapy was reported in a treatment resistant 37 year old man with schizoaffective disorder (Yovell - 1994). There are other reports of dramatic cessation of substance abuse, attenuated craving, and improved psychosocial functioning during clozapine therapy (Buckley -1998). Patients report reduction in craving, which has been considered to be due to the differential effect of clozapine on dopamine neurotransmission in nucleus accumbens, a region known to be involved in the neurobiology of craving.
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