http://linkinghub.elsevier.com/retrieve/pii/S0140673603125123
Interferons in relapsing remitting multiple sclerosis: a systematic review
The Lancet, Volume 361, Issue 9357, Pages 545-552
G.Filippini, L.Munari, B.Incorvaia, G.Ebers, C.Polman, R.D'Amico, G.Rice
They've used the Cochrane Colloboration mehodology for systematic review
of high quality trials
"
Interpretation
Recombinant interferons slightly reduce the number of patients who have
exacerbations during first year of treatment. Their clinical effect
beyond 1 year is uncertain and new trials are needed to assess their
long-term effectiveness and side-effects.
"
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