http://brain.oxfordjournals.org/cgi/reprint/120/3/393
Ferguson et al. 120 (3): 393. (1997)
A new method of assessing axon damage was used is this study.
It suggests that axonal damage, like demyelination in multiple sclerosis
is closely associated with inflammation.
That's not a great result. Remyelination can happen but regeneration of
axons in the central nervous system is rare in all but a few animals
(http://en.wikipedia.org/wiki/Wallerian_degeneration)
I'm too tired to take much from this paper.
he author's conclusions
"
The main focus for treatment of multiple sclerosis must
be the reduction of permanent disability. It is accepted that
permanent disability results from cumulative axon loss. If
this axon loss is occurring very early in the disease and
effective treatment is available, the timing of therapeutic
intervention should reflect the timing of the start of axonal
damage. This would mean treatment starting early, not being
based on the severity of the clinical state of the disease but
on preventing the cumulative assaults which result eventually
in permanent disability.
"
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